|
KMID : 0881720110260030222
|
|
Journal of Food Hygiene and Safety
2011 Volume.26 No. 3 p.222 ~ p.226
|
|
|
Evaluation of Antibacterial and Therapeutic Effects of a Sodium salts Mixture against Salmonella typhimurium in Murine Salmonellosis
|
|
Lee Yeo-Eun
Cha Chun-Nam
Park Eun-Kee
Kim Suk
Lee Hu-Jang
|
|
|
Abstract
|
|
|
|
Salmonellosis is a major bacterial zoonosis that causes self-limited enteritis to fatal infection in animals and food-borne infection and typhoid fever in humans. Multidrug-resistant strains of Salmonella spp. has increased over the last several decades and recently causes more serious problems in public health. The present study was investigated bacteriocidal effects of sodium chlorate, sodium azide, sodium cyanide, and sodium salts mixture containing sodium chlorate, sodium azide, and sodium cyanide on infection with S. typhimurium in macrophage RAW 264.7 cells, and antibacterial effects of sodium salts mixture for murine salmonellosis. In infection assay of S. typhimurium in RAW 264.7 cells, bacterial survival rates within macrophage in all treated groups was significantly reduced comparing to that of the control group with the passage of incubation time. Administration of sodium salts mixture showed a therapeutic effect for S. typhimurium infected ICR mice. The mortality of mice treated with sodium salts mixture was 70% until 12 days, while that of control mice was 100% until 9 days after S. typhimurium infection. The results of this study strongly indicate that sodium salts mixture has a potency treatment for murine salmonellosis.
|
|
|
KEYWORD
|
|
|
Salmonellosis, sodium salts mixture, therapeutic effect, ICR mouse
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|